A 65 year old female patient suffering from Rheumatoid Arthritis reported with multiple joint pains, malaise, fatigue, difficulty in breathing, difficulty in opening Jaw, difficulty in holding objects and menopausal symptoms. She had been taking multiple medications including Indomethacin, Aspirin, Prednisolone, Methotrexate etc. Treatment at Al-Sayed Hospital Rawalpindi included autologous bone marrow derived stem cell transplantation and exercise training program. Specific exercises were given four weeks before and eight weeks after stem cell transplant at our center. After one year of treatment, the patient had improvement in all of her signs and symptoms, which enabled her to discontinue several medications. There was marked improvement in her joint pain, range of motion, muscle power, grip function, functional activities and Activities of Daily Living (ADLs).